Monday, 23 Apr, 2007 Science
81
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Nano-nose to help identify illnesses

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Nanoparticles are used by U.S. researchers to 'smell' the scent of illnesses in fluids of the body. The researchers used nanoparticles of gold with different coatings to distinguish among different proteins and detect the illness, as reported by the New Scientist.

According to Vince Rotello from the University of Massachusetts the human nose has a series of receptors, which react differently to different compounds. Thus it is not a specific smell that the receptors react to, but it is a generalized response produced by the receptors, which creates the smell.

Teamed up with his colleagues from the university and with scientists from the Georgia Institute of Technology, Vince Rotello applied the same 'nose-principle' to detect proteins.

The 'nano nose' uses a system of six receptors, each one consisting of a solution with gold nano particles not larger than 2 nanometers, each one having a different coating too. Nitrogen atoms form the organic molecules which make up the coating of the nanoparticles.

Different types of proteins have different features, thus having a property to attach to various receptors, though binding with some receptors more than with others. The team's task was to identify those properties of binding for different proteins. For this purpose the team used a molecule beaming a fluorescent signal. The molecule attached to the receptor particles and then it was replaced by protein molecule when the latter bound to the receptor. This way, the more the fluorescent molecule was displaced, the more light produced. The results were subsequently analyzed by the computer.

During the experiments the scientists ran tests with 56 different proteins and proved that the signals produced by the receptors could be then used to distinguish among various proteins. The 'nano-nose' was accurate in 96 of 100 cases during these tests.

Mr. Rotello is optimistic about this accomplishment, as it could be used not just for smelling out proteins specific for a disease, but it could see the difference or the anomaly in the normal combination of proteins in the human body.

After running a series of tests with blood of sick and healthy animals, the scientists were able to identify changes in serum. They do not want to stop here and they try to make this ability statistically stable. Later on Rotello plans to make the 'nano-nose' identify different kinds of cancer cells and other diseases.

Such a nose device, sniffing out illnesses is not a novelty in the world of science and technology, as there were devices developed capable of detecting small molecules; yet the Rotello's system is the first one to detect large and complicated molecules.

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Comments:

34 votes

//42 Jul 08, 2012 06:21 AM | posted by: neha
so amazing but can i get a picture
36 votes

//41 Jun 09, 2012 11:10 AM | posted by: Kunal verma
This could help medical scientist to insert sensor technology in their field
43 votes

//40 Jan 02, 2012 10:26 PM | posted by: dapo
can i get a diagram of nano-nose
27 votes

//39 Jul 26, 2011 04:16 PM | posted by: chisom
the article is good.please can i get the picture of the nanonose and maybe the diagram if you can
27 votes

//38 May 20, 2011 11:51 PM | posted by: KAHA ISAAC
VERY NICE ONE YOU ARE FIT FOR A MODEL
23 votes

//37 Mar 03, 2011 06:48 AM | posted by: Gen017 [InfoBIG]
how about nano technology in the field of military
23 votes

//36 Feb 14, 2011 06:05 AM | posted by: Gen017 [InfoBIG]
that is great! another new invention in nanotechnology.
27 votes

//35 Jan 04, 2011 06:46 PM | posted by: gurpreet ap ch gndu
continue doing such great work
26 votes

//34 Nov 06, 2010 04:41 PM | posted by: sidra
its a very wonderful technology and help me in my prezentation
27 votes

//33 Sep 15, 2010 04:00 PM | posted by: anand
thus it very nice
27 votes

//32 Aug 12, 2010 05:32 PM | posted by: [A]nDrÖID
ah.... thanks for these text because i used these as my project and my teacher didn't say anything means it is ok ahahaha. of course this invention is awesome for this is truly unbelievable ahaaha
27 votes

//31 Aug 04, 2010 10:25 AM | posted by: sannaya
it is great.........................i got the idea of my new project.......yippe!!!!!!!!!!!!!!!!!!!!!!!!!!
26 votes

//30 Jul 21, 2010 06:58 PM | posted by: Arjun
Great but can it distinguish two diseases with similiar causative protein
27 votes

//29 Apr 07, 2010 02:30 PM | posted by: meeee.
yah i really love da idea but are there any disadvantages in this nano- nose illness detector invention? any1 who knows?
31 votes

//28 Jan 23, 2010 04:59 AM | posted by: peme1234456
goooooooooooooooooooooooooooosh
31 votes

//27 Jan 09, 2010 08:57 PM | posted by: ruts
its amanzingly fantastic invention!!!! it will help me in my seminar.....
30 votes

//26 Aug 29, 2009 11:48 AM | posted by: gina
the invention is really good!
27 votes

//25 Aug 02, 2009 10:38 AM | posted by: azl
hi
24 votes

//24 Mar 17, 2009 05:05 PM | posted by: JC
very good invetion.. It really helps me a lot in my research papare..
30 votes

//23 Feb 16, 2009 03:38 AM | posted by: mikayla
this is so incredible!i hope they can figure out how to the nano nose to identify cancer cells
25 votes

//22 Feb 09, 2009 02:52 PM | posted by: maynard
I LoVe ThIs ArTiClE So mUcH BeC. We d
22 votes

//21 Feb 02, 2009 03:22 PM | posted by: desiree anne deligero
its an interesting article.this can really help on us especially in the field of nursing and in medical.can you send me an email about your article?this can really help me in my research..thanks.this is my email add....desireeannedeligero@rocketmail.com
19 votes

//20 Jan 17, 2009 05:26 AM | posted by: Unknown
i love it. the invention is wonderful. am sure lots of people esp.in the field of medicines, nurses and doctors and even maidwives would be delighted to this for this is of great help to them. they wud no longer find hard time in checking up patients ilnesses.my salute for the author.
27 votes

//19 Dec 17, 2008 11:58 AM | posted by: celestine
nice,.,...nice invention
28 votes

//18 Dec 13, 2008 08:04 AM | posted by: nessa
it is a great invention! This new trend is a big help in the field of nursing and in medicine. keep it up....
23 votes

//17 Dec 06, 2008 03:13 PM | posted by: liuli
nothing
16 votes

//16 Dec 03, 2008 04:39 AM | posted by: e
Does anyone know who wrote this, or what the URL is?
16 votes

//15 Nov 30, 2008 11:48 PM | posted by: maazhiekh
this article is interesting. Ima use it for my science report! ty for the news---a middle skwl guy
31 votes

//14 Nov 22, 2008 07:34 AM | posted by: lyn
very good invention
21 votes

//13 Nov 04, 2008 12:16 AM | posted by: Bailey
this was so cool i did a report on this and my teacher flipped out it was so good
24 votes

//12 Aug 26, 2008 02:51 PM | posted by: marc of philippines
nice very helpful
19 votes

//11 Aug 04, 2008 03:52 AM | posted by: kristine
this is freakin' awesome....
with this we could no longer be taking so much medical treatment and check-ups..
this would be a tremendous hit to all the people around the world.. i love reading this article,..
25 votes

//10 Jul 29, 2008 09:47 AM | posted by: missy
its a nice invention...doctors will not anymore find hard time to examine the disease of the patient...it good...congratulations...
22 votes

//9 Jul 26, 2008 02:05 PM | posted by: zoe jane
Thanks for the info.,it helps me a lot......
19 votes

//8 Jul 22, 2008 08:26 PM | posted by: sanyam
thanks to this site for bringing such a great information to us
28 votes

//7 Jun 25, 2008 03:56 PM | posted by: seych
thanks, you had help me a lot in my project..
28 votes

//6 May 15, 2008 09:56 AM | posted by: adi
thanks 4 putting up the article.it's just fantastic
24 votes

//5 Apr 22, 2008 01:50 PM | posted by: ANIL KUMAR N.C
ocourse the discovery of nano-nose wil be a blasting discovery in medical field.but whether it is effective at different intensities??i mean at the starting stage and at the more critical stage?
26 votes

//4 Nov 24, 2007 01:47 AM | posted by: laith
this is an amazing invention
30 votes

//3 Nov 13, 2007 10:27 AM | posted by: TiLEt
this article is very amazing.!!!!! it never comes tomy mind that there is such a thing,nano-nose,that will be discover.nano-nose wil be very helpful to human.congratulations.
22 votes

//2 Nov 01, 2007 06:52 PM | posted by: Jeff Wolf
with my scientific knowledge, this was most pleasing to my brain!
i thank you so much for putting this article up here, my life is filled with happieness because of it
26 votes

//1 Oct 13, 2007 04:20 PM | posted by: Gelvene
elow!!!!!

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